zur Hausen Harald
Deutsches Krebsforschungszentrum, Heidelberg, Germany.
Nat Rev Cancer. 2002 May;2(5):342-50. doi: 10.1038/nrc798.
Links between human papillomaviruses (HPVs) and cervical cancer were first suspected almost 30 years ago. DNA of specific HPV types has since been found in almost all cervical cancer biopsies. HPV oncogenes that are expressed in these cells are involved in their transformation and immortalization, and are required for the progression towards malignancy. Epidemiological studies have underlined that HPVs are the main aetiological factor for cervical cancer. But how has this knowledge been translated into the clinic to allow the prevention, screening and treatment of cervical cancer?
大约30年前，人们首次怀疑人乳头瘤病毒（HPV）与宫颈癌之间存在联系。此后，几乎在所有宫颈癌活检样本中都发现了特定HPV类型的DNA。在这些细胞中表达的HPV癌基因参与了细胞的转化和永生化过程，并且是肿瘤进展所必需的。流行病学研究强调，HPV是宫颈癌的主要病因。但是，这些知识是如何转化到临床中以实现宫颈癌的预防、筛查和治疗的呢？
