Wittchen Hans-Ulrich, Kessler Ron C, Beesdo Katja, Krause Petra, Höfler Michael, Hoyer Jürgen
Institute of Clinical Psychology and Psychotherapy, Technical University of Dresden, Germany.
J Clin Psychiatry. 2002;63 Suppl 8:24-34.
Determine attitudes toward patients with generalized anxiety disorder (GAD) and major depressive episodes (MDE) in primary care; determine prevalence of GAD, MDE, and comorbid GAD/MDE among primary care patients; assess physician recognition of GAD and MDE; and describe primary care interventions for these patients.
558 primary care physicians participated in a 1-day survey. Over 20,000 patients completed a diagnostic-screening questionnaire for GAD and MDE. Physician questionnaires included a standardized clinical appraisal of somatic and psychosocial symptoms and information on past and current treatments and a prestudy questionnaire assessing experience with and attitudes toward patients with GAD and MDE.
56.9% of physicians viewed GAD as a genuine mental disorder with clinical management problems and considerable patient burden; 27.4% treated GAD patients differently from MDE patients. 5.3% of patients met criteria for GAD, 6.0% for MDE, 3.8% for pure GAD, 4.4% for pure MDE, and 1.6% for comorbid GAD/MDE. Pure GAD and MDE were associated with disability, high utilization of health care resources, and suicidality, which were even higher with comorbid GAD/MDE. Physicians recognized clinically significant emotional problems in 72.5% of patients with pure GAD, 76.5% with pure MDE, and 85.4% with comorbid GAD/MDE. However, correct diagnosis was much lower (64.3% for MDE and 34.4% for GAD). Although the majority of patients with recognized GAD or MDE were treated, only a small minority with GAD were prescribed medications or referred to specialists.
The high proportion of respondents with pure GAD is inconsistent with previous reports that GAD is usually comorbid with depression. GAD remains poorly recognized and inadequately treated. Improving the recognition and treatment of GAD in primary care patients is discussed relative to new treatments.
确定初级保健中对广泛性焦虑障碍(GAD)和重度抑郁发作(MDE)患者的态度;确定初级保健患者中GAD、MDE以及共病GAD/MDE的患病率;评估医生对GAD和MDE的识别情况;并描述针对这些患者的初级保健干预措施。
558名初级保健医生参与了一项为期1天的调查。超过20000名患者完成了一份关于GAD和MDE的诊断筛查问卷。医生问卷包括对躯体和心理社会症状的标准化临床评估以及过去和当前治疗的信息,还有一份研究前问卷,评估对GAD和MDE患者的经验和态度。
56.9%的医生认为GAD是一种存在临床管理问题且给患者带来相当负担的真正精神障碍;27.4%的医生对GAD患者的治疗方式与MDE患者不同。5.3%的患者符合GAD标准,6.0%符合MDE标准,3.8%为单纯GAD,4.4%为单纯MDE,1.6%为共病GAD/MDE。单纯GAD和MDE与残疾、高医疗资源利用率和自杀倾向相关,共病GAD/MDE时这些情况更为严重。医生在72.5%的单纯GAD患者、76.5%的单纯MDE患者和85.4%的共病GAD/MDE患者中识别出具有临床意义的情绪问题。然而,正确诊断率要低得多(MDE为64.3%,GAD为34.4%)。尽管大多数被识别出患有GAD或MDE的患者得到了治疗,但只有一小部分GAD患者被开药或转诊至专科医生处。
单纯GAD患者的高比例与之前关于GAD通常与抑郁症共病的报道不一致。GAD仍然未得到充分认识和治疗。相对于新的治疗方法,讨论了改善初级保健患者中GAD的识别和治疗情况。