Skrabal F
Dtsch Med Wochenschr. 1975 Dec 26;100(52):2649-51.
Based on repeat measurements in 11 male and 12 female normal subjects, aged 20 to 35 years, on normal, low and high sodium intake a nomogram for the relation between fasting urinary sodium creatinine ratio and plasma renin activity (PRA) is presented. The use of fasting urinary sodium creatinine ratio as index of sodium intake and hydration of the subject results in a better prediction of PRA as compared with 24-hour urinary sodium excretion. Although fasting urinary sodium creatinine ratio in normal subjects on a normal sodium intake varies between 0.2 and 1.6, a uniform increase of basal PRA is found only at a ratio of below 0.3. A ratio greater than 0.5 excludes any stimulation of PRA by low sodium intake and (or) dehydration of the subject. The shape of the nomogram should make it applicable independent of the method used for PRA assay, as soon as the variation of PRA in normal subjects with a urinary sodium creatinine ratio above 0.5 is established.
基于对11名年龄在20至35岁之间的男性和12名女性正常受试者在正常、低钠和高钠摄入情况下的重复测量，给出了一张关于空腹尿钠肌酐比值与血浆肾素活性（PRA）之间关系的列线图。与24小时尿钠排泄量相比，使用空腹尿钠肌酐比值作为受试者钠摄入和水合状态的指标能更好地预测PRA。正常钠摄入的正常受试者空腹尿钠肌酐比值在0.2至1.6之间变化，但仅在比值低于0.3时才发现基础PRA有一致升高。比值大于0.5排除了低钠摄入和（或）受试者脱水对PRA的任何刺激。一旦确定了尿钠肌酐比值高于0.5的正常受试者中PRA的变化，列线图的形式应使其可独立于用于PRA测定的方法应用。
