Pan W H, Chou J, Yeh S H, Tu C A
Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan, Republic of China.
J Hum Hypertens. 1992 Jun;6(3):199-204.
It has been proposed that the aetiology, pathophysiological status, and effective treatment of hypertensives depends on concomitant plasma renin levels. Epidemiological data are scarce on the interrelations of plasma renin activity (PRA), BP and correlates of BP in the general population. Therefore, profiles of BP correlates were compared between low PRA groups and high PRA groups in a relatively healthy population of 321 Chinese government employees working in the Taipei area, in the summer of 1987. The characteristics of the two PRA groups were similar in body mass index, urinary sodium, chloride, calcium excretion and fasting parathyroid hormone. However, the high PRA group was younger, smoked more, and had a higher mean urinary potassium excretion. Fasting plasma glucose, uric acid, and creatinine levels were lower in the low PRA group. Positive relationships between BP and urinary sodium, chloride, potassium, calcium, plasma cholesterol, triglyceride, and glucose, independent of age and body mass index, were demonstrated in the low PRA group, where a volume expansion state may exist. However, in the high PRA state, uric acid, haemoglobin concentration, insulin and parathyroid hormone level were correlated more closely with BP than in the low PRA state. Further studies are needed to examine whether the differing associations between BP and risk factors in the high and low PRA groups reflect different compensatory mechanisms or aetiological factors.
有人提出，高血压患者的病因、病理生理状态及有效治疗取决于血浆肾素水平。关于一般人群中血浆肾素活性（PRA）、血压及血压相关因素之间的相互关系，流行病学数据较少。因此，1987年夏季，在台北地区工作的321名相对健康的中国政府雇员这一人群中，比较了低PRA组和高PRA组的血压相关因素情况。两个PRA组在体重指数、尿钠、氯、钙排泄及空腹甲状旁腺激素方面特征相似。然而，高PRA组更年轻，吸烟更多，平均尿钾排泄更高。低PRA组的空腹血糖、尿酸和肌酐水平较低。在可能存在容量扩张状态的低PRA组中，血压与尿钠、氯、钾、钙、血浆胆固醇、甘油三酯和葡萄糖之间呈现正相关，且独立于年龄和体重指数。然而，在高PRA状态下，尿酸、血红蛋白浓度、胰岛素和甲状旁腺激素水平与血压的相关性比低PRA状态下更密切。需要进一步研究来检验高低PRA组中血压与危险因素之间不同的关联是否反映了不同的代偿机制或病因学因素。
