来自白首乌的新孕甾糖苷。

New pregnane glycosides from Cynanchum ascyrifolium.

作者信息

Yeo Hosup, Choi Young Hae, Kim Jinwoong

机构信息

College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Korea.

出版信息

Chem Pharm Bull (Tokyo). 2002 Jun;50(6):847-9. doi: 10.1248/cpb.50.847.

DOI:10.1248/cpb.50.847

PMID:12045346

Abstract

Two new pregnane glycosides, cynascyrosides D and E, were isolated from the roots of Cynanchum ascyrifolium. The structures of these compounds were determined on the basis of spectroscopic and chemical evidence as cynajapogenin A 3-O-alpha-L-cymaropyranosyl-(1-->4)-beta-D-digitoxopyranosyl-(1-->4)-beta-L-cymaropyranoside and cynajapogenin A 3-O-beta-D-glucopyranosyl-(1-->4)-alpha-L-diginopyranosyl-(1-->4)-beta-L-cymaropyranosyl-(1-->4)-beta-D-digitoxopyranoside.

摘要

从白首乌（Cynanchum ascyrifolium）根部分离得到两种新的孕甾糖苷，即白首乌苷D和白首乌苷E。基于光谱和化学证据，确定这些化合物的结构分别为cynajapogenin A 3 - O -α - L - 洋地黄糖基 -（1→4）-β - D - 地高辛糖基 -（1→4）-β - L - 洋地黄糖基苷和cynajapogenin A 3 - O -β - D - 葡萄糖基 -（1→4）-α - L - 洋地黄毒糖基 -（1→4）-β - L - 洋地黄糖基 -（1→4）-β - D - 地高辛糖基苷。