Akagi Masao, Omae Daichi, Tamura Yoshinori, Ueda Tetsujiro, Kumashiro Tetsuya, Urata Hidehito
Osaka University of Pharmaceutical Sciences, Takatsuki, Japan.
Chem Pharm Bull (Tokyo). 2002 Jun;50(6):866-8. doi: 10.1248/cpb.50.866.
L-Ribose was synthesized by a simple four-step method with overall yield of 76.3% from a protected L-arabinose derivative, which is a compatible intermediate for the synthesis of L-deoxyribose. The key step of this strategy is the Swern oxidation and subsequent stereoselective reduction accompanied by inversion of the 2-hydroxy group of protected L-arabinose.
