Clifford L J, Nair M G, Rana J, Dewitt D L
Department of Food Science and Human Nutrition, National Food Safety and Toxicology Center, Michigan State University, East Lansing 48824, USA.
Phytomedicine. 2002 Apr;9(3):249-53. doi: 10.1078/0944-7113-00105.
Alkamides from the roots of Echinacea purpurea (L.) Moench were examined for anti-inflammatory activity in an in vitro model system. Cyclooxygenase-I (COX-I) and cyclooxygenase-II (COX-II) inhibitory activities were assessed at pH 7 for alkamides isolated from E. purpurea roots to compare inhibitory activities between the two cyclooxygenase isozymes. At 100 microg/ml, several E. purpurea alkamides inhibited COX-I and COX-II enzymes in the range of 36-60% and 15-46%, respectively, as compared to controls. Mosquitocidal activity was assessed at 100 and 10 microg/ml, with 100% mortality against Aedes aegyptii L. larvae noted for several E. purpurea alkamides at 100 microg/ml.
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