Nazir Muhammad Muzammil, Farzeen Iqra, Zafar Saima, Fatima Sehrish, Zafar Nimrah, Ashraf Asma, Lebelo Sogolo Lucky
Department of Zoology, Government College University, Allama Iqbal Road, Faisalabad, 38000, Pakistan.
Director of School, Department of Life and Consumer Sciences, College of Agriculture and Environ-Mental Sciences, University of South Africa, Pretoria, South Africa.
Naunyn Schmiedebergs Arch Pharmacol. 2025 Feb 27. doi: 10.1007/s00210-025-03931-4.
Chicoric acid (CA), a polyphenolic compound found in chicory (Cichorium intybus), shows potential for the management of a number of diseases due to its antioxidant, anticancer, anti-inflammatory, and insulin-sensitizing properties. Chicory, a perennial member of Asteraceae family, is undoubtedly an underestimated vegetable. Currently, its primary usage is concentrated in India, Greece, Italy, and Poland. This review will concentrate on the potential of chicoric acid in different diseases through a study of the literature and in silico research. A comprehensive search of the literature was conducted using specialized and dedicated search engines. Chicoric acid has an impact on several disease types reported in vitro and in vivo. Chicoric acid has surfaced as a promising neuroprotective agent, anticancer, anti-inflammatory, antidiabetics, and antimicrobial exhibiting a broad range of actions that contribute to health and function. Bioactive compound effects on diseases are examined using network pharmacology (ADME, networking, and docking). KEGG analysis and gene ontology demonstrated that chicoric acid works by interfering with many immune system and cancer pathways. Chicoric acid had the best match with receptor proteins 1PXX and 2YCF, which suited the chemical chicoric acid best, with docking scores of - 8.46 and - 9.4, respectively. To sum up, chicoric acid is a new molecule in the medication development process.
菊苣酸（CA）是一种存在于菊苣（菊苣属）中的多酚类化合物，因其具有抗氧化、抗癌、抗炎和胰岛素增敏特性，在多种疾病的治疗方面显示出潜力。菊苣是菊科的一种多年生植物，无疑是一种被低估的蔬菜。目前，它的主要用途集中在印度、希腊、意大利和波兰。本综述将通过文献研究和计算机模拟研究，聚焦菊苣酸在不同疾病中的潜力。使用专业的搜索引擎对文献进行了全面检索。菊苣酸在体外和体内对多种疾病类型都有影响。菊苣酸已成为一种有前景的神经保护剂、抗癌、抗炎、抗糖尿病和抗菌剂，展现出有助于健康和功能的广泛作用。使用网络药理学（ADME、网络构建和对接）研究生物活性化合物对疾病的影响。KEGG分析和基因本体论表明，菊苣酸通过干扰许多免疫系统和癌症途径发挥作用。菊苣酸与受体蛋白1PXX和2YCF的匹配度最佳，最适合菊苣酸这种化学物质，对接分数分别为-8.46和-9.4。综上所述，菊苣酸是药物研发过程中的一种新分子。
