Kulathinal S B, Gasbarra Dario
Department of Epidemiology and Health Promotion, National Public Health Institute, Mannerheimintie 166, 00300 Helsinki, Finland.
Lifetime Data Anal. 2002 Jun;8(2):147-61. doi: 10.1023/a:1014887507027.
In this paper, a class of tests is developed for comparing the cause-specific hazard rates of m competing risks simultaneously in K (> or = 2) groups. The data available for a unit are the failure time of the unit along with the identifier of the risk claiming the failure. In practice, the failure time data are generally right censored. The tests are based on the difference between the weighted averages of the cause-specific hazard rates corresponding to each risk. No assumption regarding the dependence of the competing risks is made. It is shown that the proposed test statistic has asymptotically chi-squared distribution. The proposed test is shown to be optimal for a specific type of local alternatives. The choice of weight function is also discussed. A simulation study is carried out using multivariate Gumbel distribution to compare the optimal weight function with a proposed weight function which is to be used in practice. Also, the proposed test is applied to real data on the termination of an intrauterine device.
本文开发了一类检验方法,用于同时比较K(≥2)组中m种竞争风险的特定病因危险率。一个单元的可用数据是该单元的失效时间以及导致失效的风险标识符。在实际中,失效时间数据通常是右删失的。这些检验基于每种风险对应的特定病因危险率加权平均值之间的差异。未对竞争风险的依赖性做任何假设。结果表明,所提出的检验统计量具有渐近卡方分布。对于特定类型的局部备择假设,所提出的检验被证明是最优的。还讨论了权重函数的选择。使用多元耿贝尔分布进行了模拟研究,以将最优权重函数与实际中要使用的一个拟议权重函数进行比较。此外,所提出的检验应用于宫内节育器终止的实际数据。