Deacon Robert M J, Bannerman David M, Rawlins J Nicholas P
Department of Experimental Psychology, University of Oxford, United Kingdom.
Behav Neurosci. 2002 Jun;116(3):494-7. doi: 10.1037//0735-7044.116.3.494.
Rats with cytotoxic lesions of the hippocampus were given 3 anxiety tests: social interaction with a novel rat, the elevated zero-maze (a modification of the plus-maze), and hyponeophagia (eating familiar and novel foods in a novel place). Marked anxiolytic effects were seen in the social interaction and hyponeophagia tests, but not on the zero-maze. These results confirm and extend previous experiments that used traditional lesion techniques. The zero-maze result was consistent with other experiments using the plus-maze, in which intrahippocampal administrations of pharmacological agents were not anxiolytic, although variability in ethological tests may also be a factor. As the hyponeophagia test used an elevated apparatus, as in the zero- and plus-mazes, the lack of a lesion effect in the zero-maze was unlikely to have been due to an inability to relieve height-induced anxiety.
与一只陌生大鼠进行社交互动、高架零迷宫（对十字迷宫的一种改良）以及低新奇摄食（在一个新环境中进食熟悉和陌生的食物）。在社交互动和低新奇摄食测试中观察到显著的抗焦虑作用，但在零迷宫测试中未观察到。这些结果证实并扩展了先前使用传统损伤技术的实验。零迷宫测试的结果与使用十字迷宫的其他实验一致，在那些实验中，海马体内注射药理剂并没有抗焦虑作用，尽管行为学测试中的变异性也可能是一个因素。由于低新奇摄食测试使用了高架装置，与零迷宫和十字迷宫一样，零迷宫中缺乏损伤效应不太可能是由于无法缓解高度引起的焦虑。
