McHugh S B, Deacon R M J, Rawlins J N P, Bannerman D M
Department of Experimental Psychology, University of Oxford, Oxford, United Kingdom.
Behav Neurosci. 2004 Feb;118(1):63-78. doi: 10.1037/0735-7044.118.1.63.
Cytotoxic ventral hippocampal lesions produced anxiolytic effects on 4 ethologically based, unconditioned tests of anxiety in the rat (hyponeophagia, black/white 2-compartment box test, a successive alleys test that represents a modified version of the elevated plus-maze, and a social interaction test). Dorsal hippocampal lesions did not produce anxiolytic effects on these tests, suggesting a distinct specialization of function within the hippocampus. Furthermore, the effects of ventral hippocampal lesions were also distinct from those of amygdala lesions. This suggests that the effects of ventral hippocampal lesions are not simply due to direct or indirect effects on the amygdala, and that these 2 brain areas contribute differentially to a brain system (or systems) associated with the processing of fearful and/or anxiogenic stimuli.
细胞毒性腹侧海马损伤对大鼠基于行为学的4种非条件焦虑测试产生抗焦虑作用（低新食物摄取、黑白双隔箱测试、一种代表改良高架十字迷宫的连续小巷测试以及社交互动测试）。背侧海马损伤对这些测试未产生抗焦虑作用，这表明海马内存在功能的明显特化。此外，腹侧海马损伤的作用也与杏仁核损伤的作用不同。这表明腹侧海马损伤的作用并非仅仅是对杏仁核的直接或间接影响所致，且这两个脑区对与恐惧和/或焦虑源刺激处理相关的一个或多个脑系统的贡献存在差异。
