Besson-Léaud L, Fontan D, Billeaud C, Sandler B
Département de pédiatrie médicale, secteur néonatal, hôpital Pellegrin, place Amélie-Raba-Léon, 33076 Bordeaux, France.
Arch Pediatr. 2002 May;9(5):503-5. doi: 10.1016/s0929-693x(01)00833-8.
Neonatal lupus erythematosus is a rare disorder characterized by cutaneous lesions of the face and/or congenital heart block. The transplacental transfer of maternal anti-Ro/SSA, anti-La/SSB, or anti-U1RNP antibodies is responsible for the development of the disease. Few cases of neonatal lupus erythematosus with neurological involvement were reported in the medical literature.
A 36-week GA female infant presented with neonatal lupus erythematosus comprising cutaneous, hematologic and hepatic disorders with a favorable outcome. However, cutaneous atrophy and hyperpigmentation persisted. Spastic paraparesis was diagnosed at the age of six months.
The neurological lesions in neonatal lupus erythematosus could either be related to the presence of anti-Ro/SSA antibodies of maternal origin, or of anticardiolipin antibodies.
新生儿红斑狼疮是一种罕见的疾病，其特征为面部皮肤损害和/或先天性心脏传导阻滞。母体抗Ro/SSA、抗La/SSB或抗U1RNP抗体经胎盘转移是该疾病发生的原因。医学文献中报道的新生儿红斑狼疮合并神经受累的病例很少。
一名孕36周的女婴患有新生儿红斑狼疮，包括皮肤、血液和肝脏疾病，预后良好。然而，皮肤萎缩和色素沉着持续存在。六个月大时被诊断为痉挛性截瘫。
新生儿红斑狼疮的神经病变可能与母体来源的抗Ro/SSA抗体或抗心磷脂抗体的存在有关。
