Cauley Linda S, Hogan Robert J, Woodland David L
The Trudeau Institute, Saranac Lake, NY 12983, USA.
Curr Opin Investig Drugs. 2002 Jan;3(1):33-6.
Recent studies have shown that long-lived memory CD8 T-cell populations can be subdivided into two distinct groups. The central pool of resting memory cells in lymph organs has been extensively analyzed. However, a second subset of partially activated CD8 memory T-cells has recently been identified in non-lymphoid tissues. In respiratory virus models, a strong correlation between the numbers of antigen-specific T-cells in lung tissues and effective protective cellular immunity suggests that boosting the numbers of memory T-cells in non-lymphoid tissues may be a fruitful approach in vaccine development for viral infections.
最近的研究表明，长寿记忆性CD8 T细胞群体可细分为两个不同的组。淋巴器官中静止记忆细胞的中央池已得到广泛分析。然而，最近在非淋巴组织中发现了部分活化的CD8记忆T细胞的第二个亚群。在呼吸道病毒模型中，肺组织中抗原特异性T细胞数量与有效的保护性细胞免疫之间存在很强的相关性，这表明增加非淋巴组织中记忆T细胞的数量可能是病毒感染疫苗开发中的一个有效方法。
