Kohlmeier Jacob E, Woodland David L
Trudeau Institute, 154 Algonquin Avenue, Saranac Lake, New York, NY 12983, USA.
Curr Opin Immunol. 2006 Jun;18(3):357-62. doi: 10.1016/j.coi.2006.03.012. Epub 2006 Apr 17.
Memory T cells play an important role in the resolution of secondary respiratory virus infections through the production of anti-viral cytokines and the lysis of infected cells. Within the lung airways, memory T cells form an initial line of defense against secondary virus challenge by limiting early viral replication at the site of infection. Recent studies have addressed the generation and maintenance of airway memory T cells and their relationship with memory T cells in the secondary lymphoid organs. These advances have demonstrated that different memory subsets contribute to the maintenance of the airway memory T cell population and have identified molecules that influence trafficking to the lung tissue and the lung airways.
记忆T细胞在继发性呼吸道病毒感染的消退过程中发挥着重要作用，它们通过产生抗病毒细胞因子和裂解被感染细胞来实现这一作用。在肺气道内，记忆T细胞通过限制感染部位的早期病毒复制，形成了抵御继发性病毒攻击的第一道防线。最近的研究探讨了气道记忆T细胞的产生和维持及其与次级淋巴器官中记忆T细胞的关系。这些进展表明，不同的记忆亚群有助于维持气道记忆T细胞群体，并确定了影响向肺组织和肺气道迁移的分子。
