衰老性厌食的生理决定因素：来自动物研究的见解。
Physiologic determinants of the anorexia of aging: insights from animal studies.
作者信息
Horwitz Barbara A, Blanton Cynthia A, McDonald Roger B
机构信息
Section of Neurobiology, Physiology, and Behavior, Division of Biological Sciences, University of California, Davis, California 95616, USA.
出版信息
Annu Rev Nutr. 2002;22:417-38. doi: 10.1146/annurev.nutr.22.120301.071049. Epub 2002 Jan 4.
The anorexia of aging is a syndrome characterized by unexplained losses in food intake and body weight that occur near the end of life. Proposed etiologies cover a wide range of biological and psychological conditions. The observation of this phenomenon in older laboratory animals suggests that physiological changes play a significant causal role. Research on the neurochemical control of energy balance has received much attention in recent years, and age-related alterations in the neuropeptidergic effectors of food intake have been implicated in the anorexia of aging. This review provides an update on putative mechanisms underlying this dysregulation of feeding during advanced age.
衰老性厌食是一种综合征，其特征为在生命末期出现无法解释的食物摄入量和体重下降。提出的病因涵盖广泛的生物学和心理状况。在老年实验动物中对这一现象的观察表明，生理变化起着重要的因果作用。近年来，能量平衡的神经化学控制研究受到了广泛关注，与年龄相关的食物摄入神经肽效应器改变被认为与衰老性厌食有关。本综述提供了关于老年期这种进食调节异常潜在机制的最新信息。
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