Verschraegen C F
Section of Gynecologic and Medical Therapeutics, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe, Box 401, Houston, TX 77030, USA.
Curr Treat Options Oncol. 2001 Oct;2(5):385-94. doi: 10.1007/s11864-001-0043-3.
The diagnosis of mesothelioma needs to be defined histologically. The staging system has been recently redefined anatomically, but may not be applicable to extrapleural mesothelioma. Further clinicopathologic studies need to be performed to molecularly classify the disease further, according to prognosis. Intracavitary therapy has a definite role in the treatment of mesothelioma. Randomized studies of intracavitary therapies are needed to define the best treatment option. The role of complementary therapeutic modalities such as surgery and radiotherapy needs to be defined by randomized studies. There is an urgent need to better understand the biology of mesothelioma, which may lead to more focus on molecularly relevant therapies.
间皮瘤的诊断需要通过组织学来确定。分期系统最近已从解剖学角度重新定义，但可能不适用于胸膜外间皮瘤。需要进一步开展临床病理研究，以便根据预后对该疾病进行分子分类。腔内治疗在间皮瘤的治疗中具有明确作用。需要对腔内治疗进行随机研究，以确定最佳治疗方案。手术和放疗等辅助治疗方式的作用需要通过随机研究来确定。迫切需要更好地了解间皮瘤的生物学特性，这可能会使人们更加关注分子相关疗法。
