Vlasveld L T, Gallee M P, Rodenhuis S, Taal B G
Department of Medical Oncology, Netherlands Cancer Institute, Amsterdam.
Eur J Cancer. 1991;27(6):732-4. doi: 10.1016/0277-5379(91)90176-e.
4 patients with malignant peritoneal mesothelioma have been treated with intraperitoneal chemotherapy in the Netherlands Cancer Institute in the recent years. 1 patient achieved a complete remission for 36+ months and another patient had a partial remission that lasted for 10 months. Intraperitoneal chemotherapy alone or in combination with other treatment modalities may yield a response rate of 58% with 24% complete remissions in 70 patients reviewed in the literature. Although these data should be considered with caution because of the heterogenicity of the patient group treated, cisplatin-based intraperitoneal chemotherapy seems to be the best available treatment for malignant peritoneal mesothelioma at present.
近年来，荷兰癌症研究所对4例恶性腹膜间皮瘤患者进行了腹腔内化疗。1例患者实现完全缓解达36个多月，另1例患者部分缓解持续了10个月。在文献回顾的70例患者中，单独使用腹腔内化疗或与其他治疗方式联合使用，缓解率可达58%，完全缓解率为24%。尽管由于所治疗患者群体的异质性，这些数据应谨慎看待，但基于顺铂的腹腔内化疗目前似乎是恶性腹膜间皮瘤的最佳可用治疗方法。
