Ito H, Imada T, Kondo J, Amano T, Maehara T, Rino Y, Takahashi M, Shiozawa M, Hatori S, Suzuki Y
First Department of Surgery, Yokohama City University, School of Medicine, Kanagawa, Japan.
Jpn J Clin Oncol. 1998 Feb;28(2):145-8. doi: 10.1093/jjco/28.2.145.
A 71-year-old woman presented with an abdominal mass and ascites and was subsequently admitted to our hospital in June 1995. Further examination revealed that the mass was malignant and, as a result, surgery was indicated. However, the mass demonstrated widespread peritoneal dissemination, which therefore could not be resected, and pathological findings suggested a malignant peritoneal mesothelioma. The patient showed a remarkable response to combined chemotherapy with an accompanying intraperitoneal injection of cisplatin and etoposide and an intravenous injection of caffeine. However, owing to side effects, this regimen was discontinued. The patient was administered a combination drug of uracil and tegafur (UFT) in addition to intraperitoneal injection of cisplatin as an outpatient. By the 223rd day after surgery, the tumor mass and ascites had completely disappeared according to the CT. Hence chemotherapy was judged to have resulted in complete remission. Such a marked response to chemotherapy is rare in an advanced malignant peritoneal mesothelioma such as the present case. Eight months later, the tumor recurred in the pleura. Another regimen of chemotherapy with cisplatin and CPT-11 was performed. However, this treatment proved ineffective. The patient subsequently died of respiratory failure in January 1997 due to the mesothelioma. This is a case report of complete remission of malignant peritoneal mesothelioma by combined chemotherapy.
一名71岁女性因腹部肿块和腹水就诊，于1995年6月入住我院。进一步检查发现肿块为恶性，因此建议进行手术。然而，肿块显示广泛的腹膜播散，无法切除，病理结果提示为恶性腹膜间皮瘤。该患者对顺铂和依托泊苷腹腔注射联合咖啡因静脉注射的联合化疗有显著反应。然而，由于副作用，该方案被停用。患者作为门诊病人，除腹腔注射顺铂外，还接受了尿嘧啶和替加氟（UFT）的联合用药。术后第223天，根据CT检查，肿瘤肿块和腹水已完全消失。因此，化疗被判定为完全缓解。在本例这样的晚期恶性腹膜间皮瘤中，对化疗有如此显著的反应是罕见的。八个月后，肿瘤在胸膜复发。进行了另一疗程的顺铂和CPT - 11化疗。然而，该治疗无效。患者随后于1997年1月因间皮瘤死于呼吸衰竭。这是一例恶性腹膜间皮瘤联合化疗完全缓解的病例报告。
