磷脂/蛋白质锥体
Phospholipid/protein cones.
作者信息
Mishra Bijaya K, Thomas Britt N
机构信息
Department of Chemistry, Louisiana State University, Baton Rouge, Louisiana 70808, USA.
出版信息
J Am Chem Soc. 2002 Jun 19;124(24):6866-71. doi: 10.1021/ja020067h.
The presence of protein in tubule-forming solutions of the diacetylenic phospholipid 1,2-bis(10,12-tricosadiynoyl)-sn-glycero-3-phosphocholine results in the formation of hollow cones rather than the expected hollow cylinders. Differential phase-contrast video microscopy reveals that cones grow from proteinaceous nodules in a fashion similar to cylindrical tubule growth from spherical vesicles. Spatially resolved electron-beam energy-dispersive X-ray fluorescence spectroscopy shows the protein to be associated with the cone wall. Small-angle X-ray scattering shows that, like the protein-free cylinders, the cones are multilamellar with essentially identical interlamellar spacing.
在二乙炔基磷脂1,2-双（10,12-二十三碳二炔酰基）-sn-甘油-3-磷酸胆碱形成微管的溶液中存在蛋白质时，会形成中空圆锥体，而不是预期的中空圆柱体。微分相差视频显微镜显示，圆锥体从蛋白质结节生长，其方式类似于从球形囊泡生长出圆柱形微管。空间分辨电子束能量色散X射线荧光光谱显示蛋白质与圆锥体壁相关联。小角X射线散射表明，与无蛋白质的圆柱体一样，圆锥体是多层的，层间间距基本相同。
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