火鸡马立克氏病。I. 对商业鸡群的七年调查以及使用两株田间分离株进行的实验性感染

Marek's disease in turkeys. I. A seven-year survey of commercial flocks and experimental infection using two field isolates.

作者信息

Davidson Irit, Malkinson M, Weisman Y

机构信息

Division of Avian and Fish Diseases, Kimron Veterinary Institute, Bet Dagan, Israel.

出版信息

Avian Dis. 2002 Apr-Jun;46(2):314-21. doi: 10.1637/0005-2086(2002)046[0314:MSDITI]2.0.CO;2.

DOI:10.1637/0005-2086(2002)046[0314:MSDITI]2.0.CO;2

PMID:12061640

Abstract

Marek's disease virus (MDV) causes immunosuppression and tumors in chickens, but the turkey is an unusual host for the virus, and tumors caused by MDV in turkeys are unique. We describe the prevalence of turkey tumors in Israel between 1993 and 2000, their molecular diagnosis by polymerase chain reaction (PCR), and the natural distribution of herpesvirus of turkeys (HVT). Most clinical cases with tumors in commercial turkeys were diagnosed as MDV. The reproduction of Marek's disease (MD) in turkeys by two turkey MDV strains, Ar and La, was analyzed, and it was shown that these strains can induce tumors in experimental trials. The severity of experimental disease differed from those features of the original outbreak, since a less severe disease was recorded.

摘要

马立克氏病病毒（MDV）可导致鸡出现免疫抑制和肿瘤，但火鸡是该病毒的特殊宿主，MDV在火鸡中引发的肿瘤具有独特性。我们描述了1993年至2000年以色列火鸡肿瘤的患病率、通过聚合酶链反应（PCR）进行的分子诊断以及火鸡疱疹病毒（HVT）的自然分布。商业火鸡中大多数有肿瘤的临床病例被诊断为MDV。分析了两种火鸡MDV毒株Ar和La在火鸡中引发马立克氏病（MD）的情况，结果表明这些毒株在实验中可诱发肿瘤。实验性疾病的严重程度与最初疫情的特征不同，因为记录到的疾病较轻。