Joyal Christian C, Laakso Mikko P, Tiihonen Jari, Syvälahti Erkka, Vilkman Harry, Laakso Aki, Alakare Birgitta, Räkköläinen Viljo, Salokangas Raimo K R, Hietala Jarmo
Institut Philippe Pinel de Montréal, Montreal, Canada.
Biol Psychiatry. 2002 Jun 15;51(12):1005-7. doi: 10.1016/s0006-3223(01)01368-3.
Imaging studies have frequently reported volume loss of limbic structures in schizophrenia, yet there appears to be no quantitative data on entorhinal cortex volumes in patients with neuroleptic naive first-episode schizophrenia.
The volume of the entorhinal cortices of 22 control subjects and 18 patients with neuroleptic-naïve first-episode schizophrenia were measured from magnetic resonance images (MRI) scans using recently designed anatomic criteria for MRI anatomy of the entorhinal cortex.
Smaller entorhinal volumes were found bilaterally in the schizophrenic patients. This volume loss did not correlate with items on the Positive and Negative Syndrome Scale.
These data suggest early involvement of the entorhinal cortex in schizophrenia.
影像学研究经常报道精神分裂症患者边缘系统结构体积减小，但对于未使用过抗精神病药物的首发精神分裂症患者的内嗅皮质体积，似乎尚无定量数据。
使用最近设计的内嗅皮质MRI解剖学标准，从22名对照受试者和18名未使用过抗精神病药物的首发精神分裂症患者的磁共振成像（MRI）扫描中测量内嗅皮质的体积。
在精神分裂症患者双侧发现内嗅皮质体积较小。这种体积减小与阳性和阴性症状量表上的项目无关。
这些数据表明内嗅皮质在精神分裂症中早期受累。
