Joyal Christian C, Laakso Mikko P, Tiihonen Jari, Syvälahti Erkka, Vilkman Harry, Laakso Aki, Alakare Birgitta, Räkköläinen Viljo, Salokangas Raimo K R, Hietala Jarmo
Institut Philippe Pinel de Montréal (CCJ), Montreal, Canada
Biol Psychiatry. 2003 Dec 1;54(11):1302-4. doi: 10.1016/s0006-3223(03)00597-3.
The attempts to evaluate amygdaloid volumes using magnetic resonance imaging (MRI) in patients with schizophrenia have yielded highly divergent results.
Volumes of the amygdala were measured in 22 healthy participants and 18 neuroleptic-naive patients with first-episode schizophrenia, while controlling for intracranial area, gender, age, and handedness.
Persons with schizophrenia presented significantly lower amygdaloid volumes bilaterally. No significant correlations were found between the amygdaloid volumes and either the duration of the disease or the symptom severity.
Amygdaloid volume anomalies are already present in the early phases of schizophrenia.
利用磁共振成像（MRI）评估精神分裂症患者杏仁核体积的尝试得出了极为不同的结果。
对22名健康参与者和18名未服用过抗精神病药物的首发精神分裂症患者的杏仁核体积进行测量，同时控制颅内面积、性别、年龄和利手因素。
精神分裂症患者双侧杏仁核体积显著降低。杏仁核体积与疾病持续时间或症状严重程度之间均未发现显著相关性。
杏仁核体积异常在精神分裂症早期阶段就已存在。
