钌（II）配合物的抗菌和抗真菌活性

Antibacterial and antifungal activities of complexes of ruthenium (II).

作者信息

Cetinkaya B, Ozdemir I, Binbaşioğlu B, Durmaz R, Günal S

机构信息

Department of Chemistry, Ege University, Izmir, Turkey.

出版信息

Arzneimittelforschung. 1999 Jun;49(6):538-40. doi: 10.1055/s-0031-1300457.

DOI:10.1055/s-0031-1300457

PMID:10417872

Abstract

Twenty ruthenium (II) complexes (1-5) were evaluated for their in vitro antibacterial and antifungal activity against Enterococcus faecalis (ATCC 29212), Staphylococcus aureus (ATCC 29213), Escherichia coli (ATCC 25922), Pseudomonas aeruginosa (ATCC 27853), Candida albicans and Candida tropicalis. Compounds 1d, 1e, 1h, 1i and 1j showed more pronounced antimicrobial activity against Gram-positive bacteria and fungi as compared to the nitrogen donor ruthenium complexes; hydrophobic substituents were significantly more effective. None of the compounds 1-5 exhibited antimicrobial activity against the Gram-negative strains Escherichia coli (ATCC 25922) and Pseudomonas aeruginosa (ATCC 27853) with the concentrations ranging between 12.5 and 800 micrograms/ml.

摘要

评估了20种钌（II）配合物（1-5）对粪肠球菌（ATCC 29212）、金黄色葡萄球菌（ATCC 29213）、大肠杆菌（ATCC 25922）、铜绿假单胞菌（ATCC 27853）、白色念珠菌和热带念珠菌的体外抗菌和抗真菌活性。与含氮供体的钌配合物相比，化合物1d、1e、1h、1i和1j对革兰氏阳性菌和真菌表现出更显著的抗菌活性；疏水取代基的效果明显更好。化合物1-5在浓度为12.5至800微克/毫升的范围内，均未对革兰氏阴性菌株大肠杆菌（ATCC 25922）和铜绿假单胞菌（ATCC 27853）表现出抗菌活性。