Soda D M, Levy G
J Pharm Sci. 1975 Dec;64(12):1928-31. doi: 10.1002/jps.2600641203.
Inhibition of drug metabolism was studied in adult male Sprague-Dawley rats. A hydroxylated metabolite of phenylbutazone (oxyphenbutazone) inhibited the elimination of phenytoin, which is metabolized by oxidative pathways. The biotransformation of a relatively polar and only slightly plasma protein-bound drug, antipyrine, was subject to product inhibition by a hydroxylated metabolite, 4-hydroxyantipyrine. Neither oxyphenbutazone nor 4-hydroxyantipyrine measurably affected the elimination kinetics or metabolic fate of a drug (sulfanilamide) that is not metabolized by oxidative pathways.
在成年雄性斯普拉格-道利大鼠中研究了药物代谢抑制情况。保泰松的一种羟基化代谢物（羟布宗）抑制了苯妥英的消除，苯妥英是通过氧化途径进行代谢的。一种相对极性且仅与血浆蛋白轻度结合的药物安替比林的生物转化受到一种羟基化代谢物4-羟基安替比林的产物抑制。羟布宗和4-羟基安替比林均未对一种不通过氧化途径代谢的药物（磺胺）的消除动力学或代谢命运产生可测量的影响。
