Murali B, Upadhyaya U M, Goyal R K
Department of Pharmacology, L. M. College of Pharmacy, Ahmedabad 380 009, India.
J Ethnopharmacol. 2002 Jul;81(2):199-204. doi: 10.1016/s0378-8741(02)00077-6.
We have studied the effect of aqueous extract of Enicostemma. littorale (2 g/kg p.o.) daily for 6 weeks in neonatal non-insulin-dependent diabetes mellitus (NIDDM) rats. To induce NIDDM a single dose injection of STZ (70 mg/kg; i.p.) was given to the 5-day-old pups. After 3 months of STZ injection when animals were confirmed as diabetic, E. littorale was administered for 6 weeks. Fasting and fed glucose and insulin levels in NIDDM were significantly (P<0.05) higher than control rats and they were significantly decreased by the treatment with E. littorale. Results of the oral glucose tolerance test (OGTT) showed a significant (P<0.05) decrease in both AUC(glucose) and AUC(insulin) values in NIDDM treated group. Insulin sensitivity (K(ITT)) index of NIDDM control was significantly lower as compared with Wistar control and this was significantly (P<0.05) increased after treatment with E. littorale. Treatment with E. littorale also decreased the elevated cholesterol, triglyceride and creatinine levels observed in NIDDM rats. Our data suggest that aqueous extract of E. littorale is a potent herbal antidiabetic. It produces an increase in insulin sensitivity, normalizes dyslipidaemia and provides nephroprotection in diabetic rats.
我们研究了海滨千屈菜水提取物（2克/千克，口服）对新生非胰岛素依赖型糖尿病（NIDDM）大鼠连续6周的影响。为诱导NIDDM，对5日龄幼鼠腹腔注射一次链脲佐菌素（STZ，70毫克/千克）。在注射STZ 3个月后，确认动物患糖尿病，给予海滨千屈菜提取物治疗6周。NIDDM大鼠的空腹和进食后血糖及胰岛素水平显著（P<0.05）高于对照大鼠，而海滨千屈菜治疗可使其显著降低。口服葡萄糖耐量试验（OGTT）结果显示，NIDDM治疗组的AUC（葡萄糖）和AUC（胰岛素）值均显著（P<0.05）降低。NIDDM对照组的胰岛素敏感性（K（ITT））指数显著低于Wistar对照组，而海滨千屈菜治疗后该指数显著（P<0.05）升高。海滨千屈菜治疗还降低了NIDDM大鼠升高的胆固醇、甘油三酯和肌酐水平。我们的数据表明，海滨千屈菜水提取物是一种有效的抗糖尿病草药。它可提高胰岛素敏感性，使血脂异常正常化，并为糖尿病大鼠提供肾脏保护。
