Department of Anatomy, Faculty of Biomedical Sciences, Kampala International University, Western Campus, Bushenyi, Uganda.
Department of Biochemistry, Faculty of Biomedical Sciences, Kampala International University, Western Campus, Bushenyi, Uganda.
Biomed Res Int. 2020 Nov 19;2020:3189672. doi: 10.1155/2020/3189672. eCollection 2020.
Diabetes mellitus has developed into one of the debilitating diseases disturbing the health of many people living with cardiovascular diseases in modern times. The root of was investigated for its effects on alloxan-induced diabetic Wistar rats' cardiac tissues. Thirty-two (32) Wistar rats weighing between 180 and 190 g were randomly divided into four groups. The animals in groups B-D were induced with a single dose of 150 mg/kg body weight of alloxan (ALX) intraperitoneally. They were confirmed hyperglycemic after 72 hours of induction and then sustained in hyperglycemic condition for 2 weeks. Animals in groups C and D received AC intervention, as stated above, for four weeks. The body weight of the experimental animals and blood collection for glucose estimation were taken weekly for six weeks using appropriate instruments. Biochemical assays for lipid profile, antioxidant enzymatic, and nonenzymatic markers were carried out. Histopathological changes in the cardiac tissues were also studied. Administration of 150 mg/kg of ALX to experimental rats induced diabetes and significantly reduced the body weights, significantly ( < 0.05) increased the glucose level, triglyceride (TG), total cholesterol (TC), and low-density lipoprotein (LDL) levels, and decreased the levels of high-density lipoprotein (HDL) and antioxidant enzymatic markers such as catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPx) while the antioxidant nonenzymatic marker such as malondialdehyde (MDA) level was significantly increased. By contrast, rats given the ethanolic extract root of had significantly ( < 0.05) increased the body weight gain, whereas the glucose levels significantly ( < 0.05) improved in treated diabetic rats. This extract also improved the cardiovascular system of the diabetic rats by significantly decreasing TG and LDL levels, significantly ( < 0.05) increasing the HDL level, significantly reducing the cardiac contents of CAT, SOD, and GPx, and significantly ( < 0.05) decreasing MDA. Ethanolic extract root of exhibited antihyperglycemic and antihyperlipidemic activities and mitigates damage to the heart from the ALX-induced myocardial toxicity associated with type-1 diabetes.
糖尿病已经成为现代困扰心血管疾病患者健康的一种使人虚弱的疾病。研究了其对丙烯醛诱导的糖尿病 Wistar 大鼠心脏组织的影响。将 32 只体重在 180-190g 之间的 Wistar 大鼠随机分为四组。B-D 组动物腹腔注射 150mg/kg 体重的丙烯醛（ALX），诱导后 72 小时证实高血糖，然后持续高血糖 2 周。C、D 组动物如上所述接受 AC 干预 4 周。使用适当的仪器每周采集实验动物的体重和血液进行葡萄糖估计。进行脂质谱、抗氧化酶和非酶标记物的生化测定。还研究了心脏组织的组织病理学变化。向实验大鼠给予 150mg/kg 的 ALX 诱导糖尿病，并显著降低体重，显著（<0.05）增加葡萄糖水平、甘油三酯（TG）、总胆固醇（TC）和低密度脂蛋白（LDL）水平，降低高密度脂蛋白（HDL）和抗氧化酶标记物如过氧化氢酶（CAT）、超氧化物歧化酶（SOD）和谷胱甘肽过氧化物酶（GPx）的水平，而丙二醛（MDA）等抗氧化非酶标记物的水平显著升高。相比之下，给予 根乙醇提取物的大鼠体重显著（<0.05）增加，而治疗糖尿病大鼠的血糖水平显著（<0.05）改善。该提取物还通过显著降低 TG 和 LDL 水平、显著（<0.05）增加 HDL 水平、显著降低 CAT、SOD 和 GPx 的心脏含量以及显著（<0.05）降低 MDA 来改善糖尿病大鼠的心血管系统。根乙醇提取物表现出抗高血糖和抗高血脂活性，并减轻丙烯醛诱导的与 1 型糖尿病相关的心肌毒性对心脏的损伤。
