Herron Lisa L, Chakravarty Rajit, Dwan Christopher, Fitzgerald J Ross, Musser James M, Retzel Ernest, Kapur Vivek
Department of Veterinary Pathobiology and Biomedical Genomics Center, University of Minnesota, St. Paul, Minnesota 55108, USA.
Infect Immun. 2002 Jul;70(7):3978-81. doi: 10.1128/IAI.70.7.3978-3981.2002.
Staphylococcus aureus is a major cause of mastitis in bovine and other ruminant species. We here present the results of a comparative genomic analysis between a bovine mastitis-associated clone, RF122, and the recently sequenced human-associated clones, Mu50 and N315, of Staphylococcus aureus. A shotgun sequence survey of approximately 10% of the RF122 genome identified numerous unique sequences and those with elevated rates of nonsynonymous substitution. Taken together, these analyses show that there are notable differences in the genomes of bovine mastitis-associated and human clones of S. aureus and provide a framework for the identification of specific factors associated with host specificity in this major human and animal pathogen.
金黄色葡萄球菌是牛和其他反刍动物乳腺炎的主要病因。我们在此展示了对一株与牛乳腺炎相关的克隆菌株RF122，以及最近测序的与人类相关的金黄色葡萄球菌克隆菌株Mu50和N315进行比较基因组分析的结果。对RF122基因组约10%的鸟枪法测序调查鉴定出了众多独特序列以及非同义替换率升高的序列。综合这些分析表明，金黄色葡萄球菌的牛乳腺炎相关克隆菌株和人类克隆菌株的基因组存在显著差异，并为鉴定这种主要的人类和动物病原体中与宿主特异性相关的特定因子提供了一个框架。
