细胞应激与凋亡中的翻译调控。真核起始因子4E结合蛋白的作用。
Translational regulation in cell stress and apoptosis. Roles of the eIF4E binding proteins.
作者信息
Clemens M J
机构信息
Department of Biochemistry and Immunology, Cellular and Molecular Sciences Group, St George's Hospital Medical School, Cranmer Terrace, London SW17 0RE, UK.
出版信息
J Cell Mol Med. 2001 Jul-Sep;5(3):221-39. doi: 10.1111/j.1582-4934.2001.tb00157.x.
Abstract
Several mechanisms have been identified by which protein synthesis may be regulated during the response of mammalian cells to physiological stresses and conditions that induce apoptotic cell death (reviewed in Clemens et al., Cell Death and Differentiation 7, 603-615, 2000). Recent developments allow us to up-date this analysis and in this article I concentrate on one particular aspect of this regulation that has not previously been reviewed in depth in relation to apoptosis, viz. the control of the initiation of protein synthesis by eukaryotic initiation factor eIF4E and the eIF4E binding proteins (4E-BPs). Changes in the state of phosphorylation of the 4E-BPs and in the extent of their association with eIF4E occur at an early stage in the response of cells to apoptotic inducers. The review discusses the mechanisms by which these events are regulated and the significance of the changes for the control of protein synthesis, cell proliferation and cell survival.
摘要
在哺乳动物细胞对生理应激和诱导凋亡性细胞死亡的条件作出反应的过程中，已经确定了几种可能调节蛋白质合成的机制（见Clemens等人，《细胞死亡与分化》7，603 - 615，2000年综述）。最近的进展使我们能够更新这一分析，在本文中，我将重点关注这种调节的一个特定方面，即真核起始因子eIF4E和eIF4E结合蛋白（4E - BPs）对蛋白质合成起始的控制，这方面以前在凋亡相关研究中尚未得到深入综述。4E - BPs磷酸化状态的变化以及它们与eIF4E结合程度的变化发生在细胞对凋亡诱导剂反应的早期阶段。本综述讨论了这些事件的调节机制以及这些变化对蛋白质合成、细胞增殖和细胞存活控制的意义。
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