酵母丙酮酸脱羧酶催化亚硝基苯转化为N-苯基乙酰氧肟酸。
Conversion of nitrosobenzene to N-phenylacetohydroxamic acid by yeast pyruvate decarboxylase.
作者信息
Corbett M D, Cahoy J E, Chipko B R
出版信息
J Natl Cancer Inst. 1975 Nov;55(5):1247-8. doi: 10.1093/jnci/55.5.1247.
PMID:1206753
Abstract
In the presence of yeast enzyme concentrate or purified yeast pyruvate decarboxylase, nitrosobenzene was converted in part to N-phenylacetohydroxamic acid. This transformation had to be catalyzed by the enzyme, since the incubation of nitrosobenzene with the cofactor of pyruvate decarboxylase did not produce the hydroxamic acid. Similar incubations conducted with phenylhydroxylamine did not yield any detectable amounts of N-phenylacetohydroxamic acid.
摘要
在酵母酶浓缩物或纯化的酵母丙酮酸脱羧酶存在的情况下，亚硝基苯部分转化为N-苯基乙酰氧肟酸。这种转化必须由该酶催化，因为亚硝基苯与丙酮酸脱羧酶的辅因子一起孵育不会产生氧肟酸。用苯胲进行的类似孵育未产生任何可检测量的N-苯基乙酰氧肟酸。
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