Smith Jonathan D
Lab. Biochem. Gen. & Metabolism, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA.
Ageing Res Rev. 2002 Jun;1(3):345-65. doi: 10.1016/s1568-1637(02)00005-3.
One of the goals of modern medicine is to foster successful aging. In order to age successfully, one must accomplish two things: first, survive; and second, survive with good health and a sharp mind. In this discussion of apolipoproteins and aging, the focus will be on apolipoprotein E (apoE), a protein with three common isoforms, which has a large impact on longevity and successful aging. One variant of apoE (E4) is associated with increased risk for heart disease, stroke and Alzheimer's disease (AD). In addition, some of the potential mechanisms for the observed effects of apoE on aging will be discussed.
现代医学的目标之一是促进成功衰老。为了成功衰老，一个人必须完成两件事：第一，存活下来；第二，保持健康的身体和敏锐的头脑。在本次关于载脂蛋白与衰老的讨论中，重点将放在载脂蛋白E（apoE）上，它是一种具有三种常见异构体的蛋白质，对寿命和成功衰老有很大影响。apoE的一种变体（E4）与心脏病、中风和阿尔茨海默病（AD）的风险增加有关。此外，还将讨论apoE对衰老产生观察到的影响的一些潜在机制。
