Cobbs Charles S, Harkins Lualhati, Samanta Minu, Gillespie G Yancey, Bharara Suman, King Peter H, Nabors L Burt, Cobbs C Glenn, Britt William J
Surgical Service, Veterans Affairs Medical Center, Birmingham, Alabama, USA.
Cancer Res. 2002 Jun 15;62(12):3347-50.
Malignant gliomas are the most common primary brain tumors in adults, have no known etiology, and are generally rapidly fatal despite current therapies. Human cytomegalovirus (HCMV) is beta-herpesvirus trophic for glial cells that persistently infects 50-90% of the adult human population. HCMV can be reactivated under conditions of inflammation and immunosuppression, and HCMV gene products can dysregulate multiple cellular pathways involved in oncogenesis. Here we show that a high percentage of malignant gliomas are infected by HCMV and multiple HCMV gene products are expressed in these tumors. These data are the first to show an association between HCMV and malignant gliomas and suggest that HCMV may play an active role in glioma pathogenesis.
恶性胶质瘤是成人中最常见的原发性脑肿瘤，病因不明，尽管有目前的治疗方法，通常仍会迅速致命。人巨细胞病毒（HCMV）是一种对神经胶质细胞具有嗜性的β疱疹病毒，持续感染50%-90%的成年人群。HCMV可在炎症和免疫抑制条件下重新激活，其基因产物可使多个参与肿瘤发生的细胞途径失调。在此我们表明，高比例的恶性胶质瘤被HCMV感染，且这些肿瘤中表达多种HCMV基因产物。这些数据首次显示了HCMV与恶性胶质瘤之间的关联，并提示HCMV可能在胶质瘤发病机制中发挥积极作用。
