抗氧化酶活性在早产儿和通过剖宫产出生的新生儿中会降低。

Antioxidant enzyme activities are decreased in preterm infants and in neonates born via caesarean section.

作者信息

Georgeson George D, Szony Barnabás J, Streitman Károly, Varga Ilona Sz, Kovács Attila, Kovács László, László Aranka

机构信息

Mullikin Medical Center, Artesia, CA 90701, USA.

出版信息

Eur J Obstet Gynecol Reprod Biol. 2002 Jul 10;103(2):136-9. doi: 10.1016/s0301-2115(02)00050-7.

DOI:10.1016/s0301-2115(02)00050-7

PMID:12069735

Abstract

OBJECTIVES

To investigate the antioxidant defense potential of human neonates according to gestational age and mode of delivery.

STUDY DESIGN

Four study groups were established, full-term normal spontaneous vaginal delivery (FT-NSVD, n=24), full-term caesarean section (FT-CS, n=19), preterm normal spontaneous vaginal delivery (PT-NSVD, n=15) preterm caesarean section (PT-CS, n=21). The activity of catalase (CAT), glutathion peroxidase (GPX), Cu/Zn superoxide dismutase (Cu/Zn-SOD) were determined from cord blood. Statistical analysis was made by ANOVA.

RESULTS

CAT activity was significantly higher in full-term than in preterm newborns. In both the categories, neonates born via caesarean section had significantly lower CAT activities. GPX activity was significantly higher in the FT-NSVD group than in any other group. Cu/Zn-SOD activity was significantly higher in full-term neonates than in preterms and no difference was found related to the mode of delivery.

CONCLUSIONS

Prematurity and caesarean section may cause a deficiency of antioxidant defense in human newborn.

摘要

目的

根据胎龄和分娩方式研究人类新生儿的抗氧化防御潜力。

研究设计

设立四个研究组，足月正常自然阴道分娩（FT - NSVD，n = 24）、足月剖宫产（FT - CS，n = 19）、早产正常自然阴道分娩（PT - NSVD，n = 15）、早产剖宫产（PT - CS，n = 21）。从脐血中测定过氧化氢酶（CAT）、谷胱甘肽过氧化物酶（GPX）、铜/锌超氧化物歧化酶（Cu/Zn - SOD）的活性。采用方差分析进行统计分析。