脐带血氧化应激与分娩方式之间的关系。
Relationship between oxidative stress in cord blood and route of delivery.
作者信息
Inanc Fatma, Kilinc Metin, Kiran Gurkan, Guven Alanur, Kurutas Ergul Belge, Cikim I Gurkan, Akyol Omer
机构信息
Department of Biochemistry, Medical Faculty, Kahramanmaras Sutcu Imam University, Kahramanmaras, Turkey.
出版信息
Fetal Diagn Ther. 2005 Sep-Oct;20(5):450-3. doi: 10.1159/000086830.
OBJECTIVE
To investigate the effect of route of delivery on the antioxidant system of newborns.
METHODS
We used the cord blood taken during labor of 56 vaginal deliveries and 50 elective cesarean sections. The specimens were analyzed for the plasma malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT) and glucose 6-phosphate dehydrogenase (G6PD) activity and leukocyte count.
RESULTS
SOD and CAT activities were significantly higher in the elective cesarean group than the vaginal delivery group (p < 0.01 and p < 0.005, respectively), but G6PD activity was similar between the groups. Plasma MDA level was lower in the cesarean group compared to the vaginal delivery group (p < 0.001). Leukocyte count was higher in the vaginal delivery group (p < 0.005).
CONCLUSION
Our findings suggest that the route of delivery has an effect on oxidative stress in newborns exposed to oxidative stress during delivery. It can be suggested that the antioxidant system works more efficiently to overcome oxidative stress in newborns delivered via cesarean section.
目的
探讨分娩方式对新生儿抗氧化系统的影响。
方法
我们采用了56例阴道分娩和50例择期剖宫产分娩时采集的脐带血。对标本进行血浆丙二醛（MDA）、超氧化物歧化酶（SOD）、过氧化氢酶（CAT）和葡萄糖6-磷酸脱氢酶（G6PD）活性以及白细胞计数分析。
结果
择期剖宫产组的SOD和CAT活性显著高于阴道分娩组（分别为p < 0.01和p < 0.005），但两组间G6PD活性相似。剖宫产组的血浆MDA水平低于阴道分娩组（p < 0.001）。阴道分娩组的白细胞计数较高（p < 0.005）。
结论
我们的研究结果表明，分娩方式对分娩过程中暴露于氧化应激的新生儿的氧化应激有影响。可以认为，抗氧化系统在剖宫产出生的新生儿中能更有效地发挥作用以克服氧化应激。
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