Degtyarenko Alexandr M, Kaufman Marc P
Division of Cardiovascular Medicine, Department of Internal Medicine, University of California, Davis 95616, USA.
J Appl Physiol (1985). 2002 Jul;93(1):92-8. doi: 10.1152/japplphysiol.00072.2002.
In decerebrate paralyzed cats, we examined the responses of 18 spinoreticular neurons to electrical stimulation of the mesencephalic locomotor region. The activity of each of the spinoreticular neurons was recorded extracellularly from laminae IV through VI of the L(7) and S(1) spinal cord. In addition, each of the 18 spinoreticular neurons received group III afferent input from the tibial nerve. Spinoreticular projections were established for each of 18 neurons by antidromic invasion of the ventro lateral medulla at the P11 though P14 levels. The onset latencies and current thresholds for antidromic invasion from the ventro lateral medulla averaged 15.0 +/- 3.8 ms and 117 +/- 11 microA, respectively. Electrical stimulation of the mesencephalic locomotor region attenuated the spontaneous activity or the responses of each of the spinoreticular neurons to tibial nerve stimulation at currents that recruited group III afferents. Our data support the notion that thin-fiber muscle afferent input to the ventrolateral medulla is gated by a central command to exercise.
在去大脑麻痹的猫中，我们研究了18个脊髓网状神经元对中脑运动区电刺激的反应。从L（7）和S（1）脊髓的IV至VI层细胞外记录每个脊髓网状神经元的活动。此外，18个脊髓网状神经元中的每一个都接受来自胫神经的III类传入输入。通过在P11至P14水平对延髓腹外侧进行逆向侵入，为18个神经元中的每一个建立了脊髓网状投射。来自延髓腹外侧的逆向侵入的起始潜伏期和电流阈值平均分别为15.0 +/- 3.8毫秒和117 +/- 11微安。在募集III类传入神经的电流下，中脑运动区的电刺激减弱了每个脊髓网状神经元的自发活动或对胫神经刺激的反应。我们的数据支持这样的观点，即向延髓腹外侧的细纤维肌肉传入输入受运动的中枢指令控制。
