Klein C, Jr Fischer B, Fischer B, Hartnegg K
Psychophysiology Research Group, Department of Psychology, University of Freiburg, Belfortstrasse 20, 79085 Freiburg, Germany.
Exp Brain Res. 2002 Jul;145(1):121-5. doi: 10.1007/s00221-002-1105-x. Epub 2002 May 17.
This study examined the effects of methylphenidate on different measures of saccade control, using a repeated measurement design, and the experimental and statistical control of practice effects. Twenty-seven boys with ADHD (mean age 12.6 years, range 10-15 years) were randomly assigned to two testing order conditions (first on-, second off-medication versus first off-, second on-medication) and accomplished the pro-saccadic overlap and the anti-saccadic 200-ms gap tasks (200 trials each). Methylphenidate was found to reduce pro- and anti-saccadic reaction times, error correction times, and the proportion of direction errors during the anti-saccade task. Furthermore, the drug augmented the proportions of express saccades and error corrections. Overlain practice effects were found for most of these measures. Our results suggest a weakening of the fixation, and a strengthening of the "voluntary" system of saccade control by methylphenidate.
本研究采用重复测量设计，考察了哌甲酯对扫视控制不同指标的影响，以及对练习效应的实验和统计控制。27名患有注意力缺陷多动障碍的男孩（平均年龄12.6岁，范围10 - 15岁）被随机分配到两种测试顺序条件下（先服药、后停药与先停药、后服药），并完成了顺向扫视重叠和反向扫视200毫秒间隔任务（各200次试验）。研究发现，哌甲酯可缩短顺向和反向扫视反应时间、纠错时间，并减少反向扫视任务期间方向错误的比例。此外，该药物还增加了快速扫视和纠错的比例。在这些指标中的大多数都发现了叠加的练习效应。我们的结果表明，哌甲酯会削弱注视，并加强扫视控制的“自主”系统。
