Sharpe P, Asif M, Victoria A, Rowbotham D J
University of Leicester, Department of Anaesthesia, UK.
Eur J Anaesthesiol. 2002 Mar;19(3):170-2. doi: 10.1017/s0265021502000303.
Pain following the injection of propofol is a common problem. It is often treated by the coadministration of intravenous lidocaine. Iontophoresis, which facilitates the delivery of charged molecules such as lidocaine to body tissues, may be a practical alternative to lessen the pain.
The iontophoretic application of lidocaine was compared with intravenous lidocaine to assess the relative efficacy of reducing pain during propofol administration.
The incidence rate of moderate or severe pain was significantly greater in the iontophoresis group (26.7 compared with 6.9% in the intravenous lidocaine group) (P < 0.05).
The iontophoretic administration of lidocaine 60 mg does not compare favourably with lidocaine 40 mg mixed with propofol for the reduction of pain on administration of propofol.
注射丙泊酚后疼痛是一个常见问题。通常通过静脉注射利多卡因联合用药来治疗。离子电渗疗法可促进利多卡因等带电分子向身体组织的递送，可能是减轻疼痛的一种实用替代方法。
将利多卡因的离子电渗应用与静脉注射利多卡因进行比较，以评估在丙泊酚给药期间减轻疼痛的相对疗效。
离子电渗疗法组中、重度疼痛的发生率显著更高（26.7%，而静脉注射利多卡因组为6.9%）（P < 0.05）。
60毫克利多卡因的离子电渗给药在减轻丙泊酚给药时的疼痛方面，与40毫克利多卡因与丙泊酚混合使用相比并无优势。
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