Yokota S, Komatsu T, Komura Y, Nishiwaki K, Kimura T, Hosoda R, Shimada Y
Department of Anesthesiology, Nagoya University School of Medicine, Japan.
Anesth Analg. 1997 Sep;85(3):672-4. doi: 10.1097/00000539-199709000-00034.
We determined whether pretreatment with topical 60% lidocaine tape reduced the incidence of pain on injection of propofol compared with mixing intravenous lidocaine with propofol. In a randomized, double-blind trial, 90 patients were allocated to one of three groups: pretreatment with a bioocclusive dressing and administration of a premixed solution of propofol 180 mg and 2 mL of normal saline (Group A); pretreatment with 60% lidocaine tape and a premixed solution of propofol and normal saline (Group B); or pretreatment with a bioocclusive dressing and a premixed solution of propofol 180 mg and lidocaine 40 mg (Group C). The incidences of pain in Groups A, B, and C were 86.7%, 33.4%, and 20%, respectively. Group B and Group C had a significantly lower incidence of pain than Group A. There was no significant difference in the incidence of pain between Group B and Group C. There was no significant difference in the distribution of site of pain on injection of propofol among the three groups. Pretreatment with topical 60% lidocaine tape reduced the incidence of pain on injection of propofol similar to that of intravenous lidocaine mixed with propofol.
Pretreatment with topical 60% lidocaine tape reduces the pain associated with injection of propofol, a frequently used intravenous anesthetic. This approach should increase patient comfort during induction of anesthesia.
我们比较了与将静脉利多卡因与丙泊酚混合相比，局部使用60%利多卡因贴剂预处理是否能降低丙泊酚注射时的疼痛发生率。在一项随机双盲试验中，90例患者被分配到三组中的一组：使用生物封闭敷料预处理并给予丙泊酚180mg与2mL生理盐水的预混溶液（A组）；使用60%利多卡因贴剂预处理并给予丙泊酚与生理盐水的预混溶液（B组）；或使用生物封闭敷料预处理并给予丙泊酚180mg与利多卡因40mg的预混溶液（C组）。A组、B组和C组的疼痛发生率分别为86.7%、33.4%和20%。B组和C组的疼痛发生率显著低于A组。B组和C组之间的疼痛发生率无显著差异。三组间丙泊酚注射时疼痛部位的分布无显著差异。局部使用60%利多卡因贴剂预处理降低丙泊酚注射时的疼痛发生率与静脉使用利多卡因与丙泊酚混合时相似。
局部使用60%利多卡因贴剂预处理可减轻与常用静脉麻醉药丙泊酚注射相关的疼痛。这种方法应能提高麻醉诱导期间患者的舒适度。
