Morris S D
St John's Institute of Dermatology, St Thomas' Hospital, Lambeth Palace Road, London, UK.
Clin Exp Dermatol. 2002 May;27(3):220-4. doi: 10.1046/j.1365-2230.2002.01012.x.
Heat shock proteins are of fundamental importance in cutaneous biology, from protection against UV-induced damage to wound healing and repair. Heat shock proteins have important regulatory roles in the control of apoptosis, regulation of steroid aporeceptors, kinases, and other protein remodelling events. They are also implicated in the control of cell growth, and as such, are potential targets for cancer diagnosis and treatment. Currently, emphasis is being placed on the potential use of these proteins in the prevention and treatment of disease. Therapeutic manipulation of these proteins may ultimately lead to novel treatments for diseases as diverse as melanoma to epidermolysis bullosa.
热休克蛋白在皮肤生物学中至关重要，从抵御紫外线诱导的损伤到伤口愈合与修复。热休克蛋白在细胞凋亡控制、类固醇受体、激酶及其他蛋白质重塑事件的调节中发挥重要的调控作用。它们还与细胞生长的控制有关，因此是癌症诊断和治疗的潜在靶点。目前，人们正将重点置于这些蛋白质在疾病预防和治疗中的潜在用途。对这些蛋白质的治疗性操控可能最终会带来针对从黑色素瘤到大疱性表皮松解症等多种疾病的新型治疗方法。
