Polla B S
Department of Medicine, University Hospital, Geneva, Switzerland.
Dermatologica. 1990;180(3):113-7. doi: 10.1159/000248008.
Whereas hyperthermia has long been used in dermatology for the therapy of diseases as diverse as syphilis, gonorrhea, psoriasis or melanoma, the understanding of the biological effects of heat shock on the skin attracts new interests to an old field. The proteins induced by heat (stress, or heat shock proteins) appear to play a general role in protection from cellular injury and eventually in the natural defences from solar radiation. On the other hand, these ubiquitous proteins may also be involved in the immunopathology of diseases such as systemic lupus erythematosus or leprosy.
虽然热疗长期以来一直在皮肤科用于治疗梅毒、淋病、银屑病或黑色素瘤等多种疾病，但对热休克对皮肤的生物学效应的理解为这个古老领域带来了新的研究兴趣。热诱导产生的蛋白质（应激蛋白或热休克蛋白）似乎在保护细胞免受损伤以及最终在抵御太阳辐射的天然防御中发挥着普遍作用。另一方面，这些普遍存在的蛋白质也可能参与系统性红斑狼疮或麻风病等疾病的免疫病理学过程。
