Blanker Marco H, Driessen Loes F C, Bosch J L H Ruud, Bohnen Arthur M, Thomas Siep, Prins Ad, Bernsen Roos M D, Groeneveld Frans P M J
Department of General Practice, Room Ff 323, Erasmus University Rotterdam, P.O. Box 1738, 3000 DR, Rotterdam, The Netherlands.
Eur Urol. 2002 Jun;41(6):602-7. doi: 10.1016/s0302-2838(02)00172-0.
To study health status and its correlates in older men with and without lower urogenital tract dysfunction.
Cross-sectional population-based study on 1688 men aged 50-78 years without bladder or prostate cancer, radical prostatectomy, neurogenic bladder dysfunction or a negative advice from their general practitioner. Data were collected through self-administered questionnaires, including Sickness Impact Profile (SIP, three domains), Inventory of Subjective Health (ISH), International Prostate Symptom Score (IPSS) and International Continence Society (ICS) Male Sex questionnaire, medication use, socio-economic and lifestyle factors. Additional information was collected by measurement of blood pressure, transrectal ultrasonography of the prostate and uroflowmetry. Four health status domains were analyzed using the ISH and three domains of the SIP. Lower urinary tract symptoms (LUTS) were categorised using IPSS, erectile and ejaculatory dysfunction were defined using the ICS questionnaire.
All urogenital characteristics and parameters were related to at least two of the health status domains. Multivariate regression analyses yielded that LUTS and cardiac symptoms were associated with suboptimal scores of all four domains. Chronic obstructive pulmonary disease and drugs for abdominal symptoms were related to three domains; erectile and ejaculatory dysfunction, muskuloskeletal or psycho(ana)leptic drugs and marital status to two domains.
The impact of LUTS on health status was equally important as the impact of cardiac symptoms. The impact of sexual dysfunction was smaller than expected. Longitudinal studies are needed to determine how health status and illnesses interact.
研究有无下尿路功能障碍的老年男性的健康状况及其相关因素。
对1688名年龄在50 - 78岁之间、无膀胱癌或前列腺癌、未接受前列腺根治性切除术、无神经源性膀胱功能障碍且未得到全科医生负面建议的男性进行基于人群的横断面研究。通过自填问卷收集数据，包括疾病影响概况（SIP，三个领域）、主观健康量表（ISH）、国际前列腺症状评分（IPSS）和国际尿控协会（ICS）男性性功能问卷、用药情况、社会经济和生活方式因素。通过测量血压、经直肠前列腺超声检查和尿流率测定收集额外信息。使用ISH分析四个健康状况领域，使用SIP的三个领域。使用IPSS对下尿路症状（LUTS）进行分类，使用ICS问卷定义勃起和射精功能障碍。
所有泌尿生殖系统特征和参数均与至少两个健康状况领域相关。多变量回归分析显示，LUTS和心脏症状与所有四个领域的次优评分相关。慢性阻塞性肺疾病和治疗腹部症状的药物与三个领域相关；勃起和射精功能障碍、肌肉骨骼或精神（麻醉）药物以及婚姻状况与两个领域相关。
LUTS对健康状况的影响与心脏症状的影响同样重要。性功能障碍的影响小于预期。需要进行纵向研究以确定健康状况和疾病如何相互作用。
