Kunugi H, Kato T, Fukuda R, Tatsumi M, Sakai T, Nanko S
Department of Psychiatry and Genome Research Center, Teikyo University School of Medicine, Tokyo, Japan.
J Neural Transm (Vienna). 2002 Feb;109(2):213-8. doi: 10.1007/s007020200018.
Alterations of G proteins have been implicated in major psychiatric illnesses. A C825T polymorphism of a gene encoding the beta3 subunit of heterotrimeric G proteins (GNB3) was reported to be associated with several pathological conditions, such as hypertension and depressive disorder. We examined whether this polymorphism is associated with functional psychoses in a Japanese sample of 370 schizophrenics, 164 bipolars, 68 depressive patients, and 198 controls. We obtained no evidence for an association of the polymorphism with any diagnostic group.
G蛋白的改变与主要精神疾病有关。据报道，异三聚体G蛋白（GNB3）β3亚基编码基因的C825T多态性与多种病理状况相关，如高血压和抑郁症。我们在一个包含370名精神分裂症患者、164名双相情感障碍患者、68名抑郁症患者和198名对照的日本样本中，研究了这种多态性是否与功能性精神病有关。我们没有获得该多态性与任何诊断组相关的证据。
