McCullough M, Jaber M, Barrett A W, Bain L, Speight P M, Porter S R
Department of Oral Medicine, Eastman Dental Institute for Oral Health Care Sciences, UCL, University of London, 256 Gray's Inn Road, London WC1X 8LD, UK.
Oral Oncol. 2002 Jun;38(4):391-3. doi: 10.1016/s1368-8375(01)00079-3.
Previous studies have suggested a link between the presence of Candida albicans and the development of oral squamous cell carcinoma (OSCC). The aim of the present study was to assess the presence and level of colonisation of oral yeast in patients undergoing an incisional oral mucosal biopsy in order to assess whether the amount of oral yeast present correlated with the presence and degree of oral epithelial dysplastic or neoplastic change. Two hundred and twenty-three patients who were undergoing an incisional biopsy for the diagnosis of an oral mucosal lesion were enrolled in this study. Mouth swills were obtained from each patient for the presence and amount of oral yeast present. Some of the patients (44.6%) had a histopathological diagnosis of either oral epithelial dysplasia (OED) or OSCC and the frequency of oral yeast carriage was significantly greater (P<0.001) in these patients than those without histopathologically detected dysplastic or neoplastic oral lesions. Furthermore, significantly (P<0.001) more patients with OED or OSCC had a higher number of yeast (over 1000 cfu/ml) in their oral cavity than patients without any evidence of epithelial dysplasia or neoplasia histopathologically. The degree of epithelial dysplasia present in these patients also correlated with higher amounts of yeast in the oral cavity (P=0.017). The results of the present study reveal that there is an interaction between oral carriage of yeast and oral epithelial dysplasia, however it remains unclear how yeast infection influences the development and progression of dysplasia.
以往的研究表明白色念珠菌的存在与口腔鳞状细胞癌（OSCC）的发生之间存在联系。本研究的目的是评估接受口腔黏膜切开活检患者口腔酵母菌的定植情况和水平，以评估口腔中酵母菌的数量是否与口腔上皮发育异常或肿瘤性改变的存在及程度相关。本研究纳入了223例因诊断口腔黏膜病变而接受切开活检的患者。从每位患者处获取漱口水样本，以检测口腔酵母菌的存在情况和数量。部分患者（44.6%）经组织病理学诊断为口腔上皮发育异常（OED）或OSCC，这些患者口腔酵母菌携带频率显著高于（P<0.001）无组织病理学检测到的发育异常或肿瘤性口腔病变的患者。此外，经组织病理学检查，有OED或OSCC的患者口腔中酵母菌数量超过1000 cfu/ml的比例显著高于（P<0.001）无上皮发育异常或肿瘤形成迹象的患者。这些患者中上皮发育异常的程度也与口腔中较高数量的酵母菌相关（P=0.017）。本研究结果表明，口腔酵母菌定植与口腔上皮发育异常之间存在相互作用，然而酵母菌感染如何影响发育异常的发生和进展仍不清楚。
