Renou Alice, Guizard Anne-Valérie, Chabrillac Emilien, Defossez Gautier, Grosclaude Pascale, Deneuve Sophie, Vergez Sébastien, Lapotre-Ledoux Bénédicte, Plouvier Sandrine D, Dupret-Bories Agnès
Department of Surgery, University Cancer Institute Toulouse-Oncopole, Hôpitaux Universitaires de Toulouse, 31009 Toulouse, France.
French Network of Cancer Registries, 31073 Toulouse, France.
J Clin Med. 2023 Jan 30;12(3):1071. doi: 10.3390/jcm12031071.
To describe the evolution of the incidence of oral cavity cancers (OCC) among elderly patients in France between 1990 and 2018 and to compare it to the incidence of other cancers sharing the same main risk factors.
The incidence of cancers in mainland France from 1990 to 2018 was estimated from incidence data observed in every cancer registry of the Francim network. Incidence was modeled by a 2-dimensional penalized spline of age and year of diagnosis, associated with a random effect corresponding to the registry. The elderly population was divided into two groups: 70-79 years old and ≥80 years old.
There was a 72% increase in the number of OCC cases in women over 70 years of age between the periods 1990-1999 and 2010-2018. As for men, there was a stabilization in the number of cases (+2%). Over the same period, for laryngeal and hypopharyngeal cancers, there was a decrease in incidence in elderly men and an increase in elderly women, although less marked than for OCC.
Since the 1990s, the incidence of OCC has been increasing in elderly subjects in France, particularly in women. Population aging and growth or alcohol and tobacco consumption alone do not seem to explain this increase, which is not observed in the same proportions for other upper aerodigestive tract cancer subsites sharing the same main risk factors.
描述1990年至2018年法国老年人口腔癌（OCC）发病率的演变情况，并将其与具有相同主要风险因素的其他癌症发病率进行比较。
根据弗朗西姆网络各癌症登记处观察到的发病率数据，估算1990年至2018年法国本土癌症的发病率。发病率通过年龄和诊断年份的二维惩罚样条进行建模，并与对应登记处的随机效应相关联。老年人群分为两组：70 - 79岁和≥80岁。
1990 - 1999年至2010 - 2018年期间，70岁以上女性的口腔癌病例数增加了72%。男性病例数则趋于稳定（增长2%）。同期，喉癌和下咽癌方面，老年男性发病率下降，老年女性发病率上升，不过增幅小于口腔癌。
自20世纪90年代以来，法国老年人口腔癌发病率一直在上升，尤其是女性。人口老龄化以及单纯的酒精和烟草消费似乎无法解释这种增长，在具有相同主要风险因素的其他上消化道癌症亚部位中未观察到如此比例的增长。
