Hebbar Pragati B, Pai Anuradha, D Sujatha
Department of Oral Medicine and Radiology, The Oxford Dental College and Hospital, Bangalore, India.
J Oral Sci. 2013;55(2):157-60. doi: 10.2334/josnusd.55.157.
The present study aimed to assess the presence and level of colonization of Candida in patients with oral mucosal lesions, to determine the presence or absence of candidal hyphae in biopsy specimens and to correlate the degree of epithelial dysplasia with the number of colony-forming units of Candida. We performed a prospective study including 50 patients diagnosed as having oral potentially malignant and malignant disorders. These patients had lesions such as leukoplakia, lichen planus, lichenoid reaction, verrucous carcinoma and oral squamous cell carcinoma. An oral swish with 10 mL of normal saline was performed, and this was collected in a sterile plastic container. Candidal colony-forming units were assessed in the specimen. This was followed by a biopsy of the lesion, which was sent for histopathologic examination for dysplasia and severity, and to assess the presence or absence of candidal hyphae. The results of the present study revealed a correlation between higher Candida colonization and increasing severity of dysplasia. An effort was made to correlate Candida by histologic and mycologic means with epithelial dysplasia. If such a correlation is strongly established, then the importance of antimycotic therapy can be emphasized to avoid deterioration.
本研究旨在评估口腔黏膜病变患者念珠菌的定植情况及水平，确定活检标本中念珠菌菌丝的有无，并将上皮发育异常程度与念珠菌菌落形成单位数量进行关联。我们进行了一项前瞻性研究，纳入了50例被诊断为患有口腔潜在恶性和恶性疾病的患者。这些患者患有白斑、扁平苔藓、苔藓样反应、疣状癌和口腔鳞状细胞癌等病变。用10 mL生理盐水进行口腔含漱，并将其收集在无菌塑料容器中。对标本中的念珠菌菌落形成单位进行评估。随后对病变进行活检，将其送去进行组织病理学检查以评估发育异常情况和严重程度，并评估念珠菌菌丝的有无。本研究结果显示念珠菌定植增加与发育异常严重程度增加之间存在关联。我们努力通过组织学和真菌学方法将念珠菌与上皮发育异常进行关联。如果能强有力地确立这种关联，那么就可以强调抗真菌治疗以避免病情恶化的重要性。
