清醒大鼠的遥测小肠动力记录：一种新方法。
Telemetric small intestinal motility recording in awake rats: a novel approach.
作者信息
Meile T, Zittel Tilman T
机构信息
University Hospital, Department of General and Transplantation Surgery, Hoppe-Seyler-Strasse 3, D-72076 Tübingen, Germany.
出版信息
Eur Surg Res. 2002 May-Jun;34(3):271-4. doi: 10.1159/000063400.
INTRODUCTION
Ideally, gastrointestinal motility recording should be done in freely moving, stress-free animals. However, no such method is currently available for rats.
METHODS
Two NiCr electrodes were sutured to the jejunum and connected to an implantable electromyographic (EMG) transmitter in rats. EMG signals were radio-transmitted to a receiver placed at the bottom of the rats' home cages.
RESULTS
Fasting and postprandial jejunal EMG signals could be detected by telemetry. Phase III contractions of the MMC were easy to identify visually and occurred at a rate of about 4.8 per hour. Feeding disrupted the phasic contraction pattern 15 min after the start of food intake and lasted for 2 h. The motility index (MI, area under the curve) was calculated and increased postprandially.
CONCLUSION
Telemetric transmission of rat gastrointestinal EMG signals is feasible and results are comparable to those given in the literature.
引言
理想情况下，胃肠动力记录应在自由活动、无应激的动物身上进行。然而，目前尚无适用于大鼠的此类方法。
方法
将两根镍铬电极缝合到大鼠空肠，并连接至植入式肌电图（EMG）发射器。EMG信号通过无线电传输至置于大鼠饲养笼底部的接收器。
结果
通过遥测可检测到空腹和餐后空肠EMG信号。MMC的Ⅲ期收缩易于肉眼识别，发生率约为每小时4.8次。进食在开始摄入食物后15分钟扰乱了相性收缩模式，并持续2小时。计算了动力指数（MI，曲线下面积），且餐后增加。
结论
大鼠胃肠EMG信号的遥测传输是可行的，结果与文献报道相当。
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