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诺氏疟原虫裂殖体抗原的定位与化学特性分析

Localization and chemical characterization of Plasmodium knowlesi schizont antigens.

作者信息

Deans J A, Cohen S

出版信息

Bull World Health Organ. 1979;57 Suppl 1(Suppl):93-100.

PMID:120777
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2395728/
Abstract

The identification of malarial antigens that induce protective immunity could provide a rational basis for developing an effective antimalarial vaccine as well as specific serodiagnostic tests indicative of clinical immune status. Since protective immunity is probably induced by stage-dependent rather than stage-independent antigens, the antigenic composition of different stages of Plasmodium knowlesi has been compared, and a limited chemical characterization undertaken. This information should provide some insight into the types of preparative procedure appropriate for the purification of functionally important malarial antigens.

摘要

鉴定能诱导保护性免疫的疟疾抗原可为开发有效的抗疟疫苗以及指示临床免疫状态的特异性血清诊断试验提供合理依据。由于保护性免疫可能是由阶段依赖性而非阶段非依赖性抗原诱导的，因此已对诺氏疟原虫不同阶段的抗原组成进行了比较，并进行了有限的化学特性分析。这些信息应能为适合纯化具有功能重要性的疟疾抗原的制备程序类型提供一些见解。

相似文献

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Localization and chemical characterization of Plasmodium knowlesi schizont antigens.诺氏疟原虫裂殖体抗原的定位与化学特性分析
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2
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Am J Trop Med Hyg. 1977 May;26(3):373-6. doi: 10.4269/ajtmh.1977.26.373.
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Bull World Health Organ. 1980;58(3):439-44.
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Immunoelectrophoretic analysis of erythrocytic stages of Plasmodium yoelii and P. chabaudi.
Z Parasitenkd. 1984;70(5):599-608. doi: 10.1007/BF00926590.
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Plasmodium knowlesi variant antigens are found on schizont-infected erythrocytes but not on merozoites.诺氏疟原虫变异抗原存在于裂殖体感染的红细胞上，而不存在于裂殖子上。
Infect Immun. 1981 Jul;33(1):275-84. doi: 10.1128/iai.33.1.275-284.1981.

本文引用的文献

1
Antigenic variation and protective immunity in Plasmodium knowlesi malaria.诺氏疟原虫疟疾中的抗原变异与保护性免疫
Immunology. 1972 Oct;23(4):503-21.
2
Electrophoretic analysis of the major polypeptides of the human erythrocyte membrane.人红细胞膜主要多肽的电泳分析。
Biochemistry. 1971 Jun 22;10(13):2606-17. doi: 10.1021/bi00789a030.
3
Alterations in the permeability of mouse erythrocytes infected with the malaria parasite, Plasmodium berghei.感染疟原虫伯氏疟原虫的小鼠红细胞通透性的改变。
Int J Parasitol. 1975 Oct;5(5):537-40. doi: 10.1016/0020-7519(75)90046-6.
4
In vitro isolation of Plasmodium knowlesi merozoites using polycarbonate sieves.使用聚碳酸酯筛网体外分离诺氏疟原虫裂殖子
Parasitology. 1975 Dec;71(3):475-81. doi: 10.1017/s0031182000047235.
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Antibody mediated mechanisms of immunity to malaria induced by vaccination with Plasmodium knowlesi merozoites.用诺氏疟原虫裂殖子疫苗接种诱导的疟疾免疫的抗体介导机制。
Immunology. 1978 Jan;34(1):77-86.
6
Antigenic analysis of sequential erythrocytic stages of Plasmodium knowlesi.诺氏疟原虫连续红细胞期的抗原分析。
Parasitology. 1978 Dec;77(3):333-44. doi: 10.1017/s0031182000050290.
7
Current status of the immunology of blood and tissue protozoa. II. Plasmodium.血液及组织原生动物免疫学的现状。II.疟原虫。
Exp Parasitol. 1977 Aug;42(2):473-446. doi: 10.1016/0014-4894(77)90095-9.

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