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[苯甲酸雌二醇和丙酸双氢睾酮与丙酸睾酮对成年去卵巢母羊诱导雄性样性行为的比较]

[Comparison of estradiol benzoate and dihydrotestosterone propionate with testosterone propionate on the induction of male-like sexual behavior in female sheep ovariectomized as adults].

作者信息

Fabre C, Signoret J P

出版信息

C R Acad Hebd Seances Acad Sci D. 1978 May 29;286(21):1527-30.

PMID:99256
Abstract

Daily I/M injections of 200 microgram of oestradiol benzoate induce in female Sheep, ovariectomized as adults, male-like sexual reactions similar to what is obtained with 10 mg testosterone propionate per day. Simultaneously, a permanent female sexual receptivity is observed. Oestradiol benzoate at the dose of 20 microgram/day, and dihydrotestosterone propionate (10 mg/day) are both totally ineffective. The result support the hypothesis of the necessity of the aromatization of testosterone for the action on sexual behaviour.

摘要

每天对成年后进行卵巢切除的雌性绵羊进行200微克苯甲酸雌二醇的皮下注射或肌肉注射,会引发类似雄性的性行为反应,这与每天注射10毫克丙酸睾酮所产生的反应相似。同时,还观察到了永久性的雌性性接受能力。每天20微克剂量的苯甲酸雌二醇以及丙酸双氢睾酮(每天10毫克)均完全无效。这些结果支持了睾酮芳香化对于性行为作用的必要性这一假说。

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