5-羟色胺神经元系统参与Δ⁹-四氢大麻酚诱导的空间记忆损伤。
Involvement of 5-hydroxytryptamine neuronal system in Delta(9)-tetrahydrocannabinol-induced impairment of spatial memory.
作者信息
Egashira Nobuaki, Mishima Kenichi, Katsurabayashi Shutaro, Yoshitake Tomohiro, Matsumoto Yoshiaki, Ishida Junichi, Yamaguchi Masatoshi, Iwasaki Katsunori, Fujiwara Michihiro
机构信息
Department of Physiology and Pharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Japan.
出版信息
Eur J Pharmacol. 2002 Jun 12;445(3):221-9. doi: 10.1016/s0014-2999(02)01755-7.
The present study investigated the involvement of the serotonin (5-hydroxytryptamine, 5-HT) neuronal system in the Delta(9)-tetrahydrocannabinol-induced impairment of spatial memory in the eight-arm radial maze in rats. Delta(9)-Tetrahydrocannabinol (6 mg/kg, i.p.), which impairs spatial memory, significantly increased the 5-HT content in the ventral hippocampus. A microdialysis study showed that Delta(9)-tetrahydrocannabinol (6 mg/kg, i.p.) decreased 5-HT release in the ventral hippocampus. The 5-HT precursor, 5-hydroxy-L-tryptophan (5-HTP; 50 mg/kg, i.p.), the 5-HT re-uptake inhibitor, clomipramine (0.01 and 0.1 mg/kg, i.p.), the 5-HT receptor agonist, 5-methoxy-N,N-dimethyltryptamine (5-MeODMT; 0.01 and 0.03 mg/kg, i.p.), and the 5-HT(2) receptor agonist, 1-(2,5-dimethoxy 4-iodophenyl)-2-amino propane (DOI; 10 microg/kg, i.p.), significantly attenuated the Delta(9)-tetrahydrocannabinol-induced impairment of spatial memory. These results suggest that the 5-HT neuronal system may be involved in the Delta(9)-tetrahydrocannabinol-induced impairment of spatial memory.
本研究调查了血清素（5-羟色胺，5-HT）神经元系统在大鼠八臂放射状迷宫中，Δ⁹-四氢大麻酚诱导的空间记忆损害中的作用。损害空间记忆的Δ⁹-四氢大麻酚（6毫克/千克，腹腔注射）显著增加了腹侧海马体中的5-HT含量。一项微透析研究表明，Δ⁹-四氢大麻酚（6毫克/千克，腹腔注射）降低了腹侧海马体中5-HT的释放。5-HT前体5-羟基-L-色氨酸（5-HTP；50毫克/千克，腹腔注射）、5-HT再摄取抑制剂氯米帕明（0.01和0.1毫克/千克，腹腔注射）、5-HT受体激动剂5-甲氧基-N，N-二甲基色胺（5-MeODMT；0.01和0.03毫克/千克，腹腔注射）以及5-HT₂受体激动剂1-（2,5-二甲氧基-4-碘苯基）-2-氨基丙烷（DOI；10微克/千克，腹腔注射）均显著减轻了Δ⁹-四氢大麻酚诱导的空间记忆损害。这些结果表明，5-HT神经元系统可能参与了Δ⁹-四氢大麻酚诱导的空间记忆损害。
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