Yang X, Lu Y, Xie D
Department of Otolaryngology, Second Affiliated Hospital, Hunan Medical University, Changsha 410011.
Hunan Yi Ke Da Xue Xue Bao. 1999;24(5):465-7.
In order to evaluate the preventive and therapeutic effects of Radix Salvia Miltiorrhizae on radiation damage of the cochlea, guinea pigs were divided into 3 groups. Group 1 was treated by radiation added with Radix Salvia Miltiorrhizae. Group 2 was radiated alone, and Group 3 was control. Group 1 and Group 2 were radiated with a single dose of gamma radiation(60 Gy). Morphological and functional observation of the cochleae was performed in two weeks after radiation. The result showed that the changes of complex action potential(CAP) and the cochlear structure were slight in Group 1, but obvious changes were found in Group 2. There was a significant difference in CAP response threshold and incidence of the cochlear hair cell loss between Group 1 and Group 2 (P < 0.01). These results suggest that Radix Salvia Miltiorrhiza may prevent radiation-induced cochlea damage. Its protective mechanisms may be cleaning free radicals, blocking calcium channel and improving microcirculation of the cochlea.
为评价丹参对耳蜗辐射损伤的防治作用，将豚鼠分为3组。第1组采用辐射加丹参治疗。第2组单独接受辐射，第3组为对照组。第1组和第2组接受单次γ辐射（60 Gy）。辐射后两周对耳蜗进行形态学和功能观察。结果显示，第1组复合动作电位（CAP）和耳蜗结构变化轻微，而第2组有明显变化。第1组和第2组在CAP反应阈值和耳蜗毛细胞丢失发生率方面存在显著差异（P<0.01）。这些结果表明，丹参可能预防辐射诱导的耳蜗损伤。其保护机制可能是清除自由基、阻断钙通道和改善耳蜗微循环。
