Lam Chen-Fuh, Sviri Sigal, Ilett Kenneth F, van Heerden Peter V
Department of Pharmacology, University of Western Australia, Crawley, WA 6009, Australia.
Expert Opin Investig Drugs. 2002 Jul;11(7):897-909. doi: 10.1517/13543784.11.7.897.
Selective pulmonary vasodilators cause vasodilatation limited to the pulmonary vasculature, within well-ventilated lung regions. Selective pulmonary vasodilators ideally cause only a minimal effect on the systemic circulation and improve ventilation/perfusion matching. NONOates are a novel group of chemical compounds that spontaneously and continuously release nitric oxide under physiological conditions, over periods of up to 24 h. Inhaled NONOates retain the benefits of gaseous nitric oxide without many of its therapeutic disadvantages. This review focuses on the therapeutic potential of inhaled NONOates in pulmonary hypertension, other lung conditions associated with right ventricular dysfunction and in asthma. The potential toxicity of NONOates is also discussed.
选择性肺血管扩张剂可使通气良好的肺区域内的肺血管发生局限性血管扩张。理想情况下，选择性肺血管扩张剂对体循环仅有极小影响，并能改善通气/血流匹配。NONOates是一类新型化合物，在生理条件下可自发持续释放一氧化氮长达24小时。吸入NONOates保留了气态一氧化氮的益处，同时避免了其许多治疗方面的缺点。本综述重点关注吸入NONOates在肺动脉高压、其他与右心室功能障碍相关的肺部疾病以及哮喘中的治疗潜力。还讨论了NONOates的潜在毒性。
